The royal figure gives up his honor as Duke of York.
The royal is relinquishing his titles, including the Duke of York, he has stated in a personal statement.
He has been under growing pressure over his connections with convicted criminal Epstein, with requests for the Palace to take steps against him.
That now looks to have caused the figure deciding to of his own accord hand back his honors and to surrender membership of the Order of the Garter.
In his message he said he continued to "vigorously refute the claims against me".
"In talks with the King, and my immediate and broader family, we have agreed the persistent claims about me divert from the work of His Majesty and the Royal Family," said a announcement from Prince Andrew.
"I have chosen, as I always have, to put my duty to my kin and land first.
"I support my choice five years ago to step back from official duties.
"With the monarch's approval, we think I must now go a further step. I will therefore no longer hold my honor or the honours which have been conferred upon me. As I have said earlier, I vigorously deny the allegations against me."
Prince Andrew has encountered a number of issues, among them a lawsuit he ended with the plaintiff, doubts about his money matters and his involvement with an suspected Chinese spy.
He will remain a royal - but will cease to be the the Duke, a designation bestowed from his the late Queen, the late Queen Elizabeth.
Andrew had already ended to be a "participating figure" and had lost the use of his royal style and no longer was seen at official royal events. His role now will be even more lessened.
His ex-wife will be known as Ferguson and no longer the Duchess, but their children will continue to have the honor of royal princess.
He has faced strong scrutiny over his links with notorious figure Epstein, more in recent times involving questions about when he had really ended communication.
In his media discussion, the royal had said that he had severed all links with the financier after they had been seen together in NYC in the end of 2010.
But messages sent in the following year later emerged suggesting that Andrew had confidentially stayed in communication with the financier, such as sending a message: "Keep in close touch and we'll meet again soon!"
There had been mounting frustration in Buckingham Palace at the issues that continued to surround the prince.
Next week a posthumous memoir by Giuffre will be released which is likely to draw further attention on his involvement with the plaintiff and the financier.
